PATENT: Using sBCMA to Monitor Myeloma
Circulating B-cell maturation antigen (BCMA) levels are high enough in most MM patients to interfere with anti-BCMA antibody-based treatments from reaching the MM tumor cells.
BCMA is central to the survival of multiple myeloma cells.1Â BCMA, BAFF, and APRIL are all expressed at significantly higher levels in patients with multiple myeloma than in healthy individuals.1,5 Overexpression leads to upregulation of anti-apoptotic proteins and the survival of multiple myeloma cells.1 Upregulation of BCMA also correlates with disease burden and poor prognosis in multiple myeloma.1
PATENT: Combination of JAKiâ€™s with Immunomodulatory Agents for Anti-cancer Applications
JAK inhibitors (JAKi) have a proven track record in myelofibrosis with an efficacy and safety profile making them attractive in MM.
JAK inhibitors can â€˜rescue the responseâ€™ in patients who are progressing on immunomodulatory agents.
JAK inhibitors have the benefit of antagonizing the lethargy affects of immunomodulatory agents and make the patients feel better with more energy.
PATENT: Modulating Gamma Secretase Inhibitors (GSIs) to Improve BCMA-targeted Therapies
Gamma secretase (GS) is responsible for shedding of BCMA from the cell surface.Â GSIs prevent the â€˜sheddingâ€™ of cellular-bound BCMA.
Therapies targeting BCMA can see their activities modulated (potentially enhanced) by this anti-shedding affect.Â At very low concentrations, inhibitors of GS block shedding of BCMA from multiple myeloma (MM) cells in vitro resulting in markedly lower supernatant levels of this protein.
1. Cho S-F, Anderson KC, Tai Y-T. Front Immunol. 2018;9:1821.
2. Huang H-W, Chen C-H, Lin C-H, Wong C-H, Lin K-I. Proc Natl Acad Sci U S A. 2013;110(27):10928-109333.
3. Hatzoglou A, Roussel F, Bourgeade M-F, et al. J Immunol. 2000;165(3):1322-1330.
4. Coquery CM, Erickson LD. Crit Rev Immunol. 2012;32(4):287-305.
5. Moreaux J, Legouffe E, Jourdan E, et al. Blood. 2004;103(8):3148-3157.